Adge Contact Leadership News Therapeutic Focus Assets
Addressing Significant Unmet Medical Needs for Longer, Healthier Lifespans.
ASSET
Asset Summary
  • A clinical stage orally available small molecule with best-in-class safety
  • Mechanism of action supports application in diseases with major unmet medical needs
  • Focus on obesity and metabolic syndrome
  • Additional rare disease opportunities
THERAPEUTIC
Therapeutic Focus
Obesity
Metabolic Syndrome
NEWS
News

2023

April 30, 2023 16:00 PDT
Adge Pharmaceuticals prepares to evaluate elocalcitol for the treatment of obesity and metabolic syndrome.

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Leadership
Leadership
Kalev Kask PhD
CEO
Dr. Kalev Kask is the founder and Chief Executive Officer of Adge. Before Adge he led the growth of EGeen International into a global clinical research organization as its founding Chief Executive Officer. He is an accomplished dealmaker with an extensive scientific command and commercial acumen. Dr. Kask completed his postgraduate training at Stockholm University, Stanford University and Max-Planck Institute for Medical Research in Heidelberg. Dr. Kask is an inventor on multiple patents and has authored numerous scientific publications.
Adge has assembled an experienced team of drug development experts to take elocalcitol through clinical trials in obesity and related indications.
PIPELINE
Pipeline
pipeline
OBESITY
Obesity
A disease of excessive fat accumulation resulting in health deterioration.
obesity
METABOLIC
Metabolic Syndrome

Presence of at least any three of the following:

  • Visceral fat reflected in disproportionate fat tissue in and around the abdomen
  • Insulin resistance
  • Glucose intolerance
  • Atherogenic dyslipidemia (high triglycerides (≥150 mg/dL)
  • High LDL cholesterol and low HDL cholesterol (≤50 mg/dL)
  • High blood pressure (≥130/85 mmHg)
OSTEOGENESIS
Osteogenesis Imperfecta
  • Genetic disorder of bone formation characterized by bone fragility and low bone mass
  • Mutations in type I collagen, collagen-associated proteins and other genes regulating osteoblast activity and signaling
  • US prevalence of 20,000 to 50,000
  • No treatment available
  • New bone formation is required for success in osteogenesis imperfecta
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